ABSTRACT
Monkeypox virus is DNA virus of Orthopoxvirus. The Monkeypox is zoonosis disease first diagnosed in the Democratic Republic of the Congo in 1970 and originally transmitted from Vertebrate Reservoir. In 1796, Edward Jenner was the first physician achieved vaccine and prove its efficacy through exposing James Phipps to smallpox after immunization. The current study revises the vaccine efficacy and mortality rate of monkeypox. It is mainly transmitted from Squirrels to human and cause mortality rate ranging from 2.7 to 10.1%. Globally, it estimated 4.4% the mortality rate of Monkeypox cases. Based on current review study, the effectiveness of smallpox vaccine in preventing the monkeypox is quite variable due to several selective clinical cases criteria such as history taking and clinical features and laboratory investigation, which modify the statistical result of the vaccine efficacy. The current study clarifies the faults of calculation by eliminating several reasons and estimating the effectiveness of vaccine in the household and find it to be 16.3% whereas total Vaccine efficacy is 0.6%. Using preventive measures are the first line to avoid infection therefore healthcare workers must adhere to infection control precautions. A current study warns scientists to create monkeypox vaccine rather than depending on smallpox vaccine effectiveness due to lacking of current vaccine effectiveness evidence and treatment.